Oral Exposure to Drugs with Immune-Adjuvant Potential Induces Hypersensitivity Responses to the Reporter Antigen TNP-OVA
Abstract
Immune-mediated drug hypersensitivity reactions are important causes of black box warnings and drug withdrawals. Despite the high demand for preclinical screening tools, no validated in vitro or in vivo models are available. In the current study, we used a previously described oral administration model using trinitrophenyl-ovalbumin (TNP-OVA) as an antigen to report immuno-adjuvating effects of the analgesic drug acetaminophen (APAP) and its...
Paper Details
Title
Oral Exposure to Drugs with Immune-Adjuvant Potential Induces Hypersensitivity Responses to the Reporter Antigen TNP-OVA
Published Date
Mar 14, 2011
Journal
Volume
121
Issue
2
Pages
312 - 319
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