Silencing T-bet Defines a Critical Role in the Differentiation of Autoreactive T Lymphocytes
Abstract
As a means of developing therapies that target the pathogenic T cells in multiple sclerosis (MS) without compromising the immune system or eliciting systemic side effects, we investigated the use of T-bet-specific antisense oligonucleotides and small interfering RNAs (siRNA) to silence T-bet expression in autoreactive encephalitogenic T cells and evaluated the biological consequences of this suppression in experimental autoimmune...
Paper Details
Title
Silencing T-bet Defines a Critical Role in the Differentiation of Autoreactive T Lymphocytes
Published Date
Nov 1, 2004
Journal
Volume
21
Issue
5
Pages
719 - 731
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Notes
History