Effects of Different Nylestriol/Levonorgestrel Dosages on Bone Metabolism in Female Sprague–Dawley Rats with Retinoic Acid‐Induced Osteoporosis

Objective. To determine an optimal dosage combination for a nylestriol/levonorgestrel (NYL/LNG) regimen in the treatment of female Sprague–Dawley (SD) rats with retinoic acid (RA)‐induced osteoporosis in order to examine the rationale of NYL/LNG use for postmenopausal women. Methods. This study included two sets of experiments; one was designed to confirm the success of the RA‐induced osteoporosis model involving 48 SD rats, and the other to...