Cancer of the pancreas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Published on Sep 1, 2015in Annals of Oncology32.976
路 DOI :10.1093/ANNONC/MDV295
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6 Authors (Lola Rahib, ..., Lynn M. Matrisian)
#1Nicola Waddell (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 38
#2Marina Pajic (Garvan Institute of Medical Research)H-Index: 38
Last. Kelly Quek (UQ: University of Queensland)H-Index: 12
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Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole-genome sequencing and copy number variation (CNV) analysis of 100 pancreatic ductal adenocarcinomas (PDACs). Chromosomal rearrangements leading to gene disruption were prevalent, affecting genes known to be important in pancreatic cancer (TP53, SMAD4, CDKN2A, ARID1A and ROBO2) and new candidate drivers of pancreatic carcinogenesis (KDM6A and PREX2). Patterns of structural variation (var...
#1Jean Robert DelperoH-Index: 30
#2Jean Marie BoherH-Index: 12
Last. Fran莽ois Paye (University of Paris)H-Index: 41
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Background Venous resection (VR) during pancreatectomy has been reported to neither increase mortality nor morbidity and to provide similar survival outcomes in same stage tumors. However, controversy remains regarding the indications for up-front surgery according to the degree of venous involvement.
#1Vikas Dudeja (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 39
#2Peter J. Allen (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 100
Due to increasing utilization of cross-sectional imaging, asymptomatic pancreatic cysts are frequently being diagnosed. Many of these cysts have premalignant potential and offer a unique opportunity for cancer prevention. Mucinous cystic neoplasm and intraductal papillary mucinous neoplasm are the major premalignant cystic neoplasms of pancreas. The prediction of the risk of malignancy (incidental and future risk of malignant transformation) and balancing the risks of watchful waiting with that ...
#1Arvind Rishi (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 10
#2Michael Goggins (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 121
Last. Ralph H. Hruban (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 213
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Pancreatic neoplasms are morphologically and genetically heterogeneous and include a wide variety of tumors ranging from benign to malignant with an extremely poor clinical outcome. Our understanding of these pancreatic neoplasms has improved significantly with recent advances in cancer sequencing. Awareness of molecular pathogenesis brings new opportunities for early detection, improved prognostication, and personalized gene-specific therapies. Here we review the pathological classification of ...
#1Theresa P. Yeo (Thomas Jefferson University Hospital)H-Index: 8
Pancreatic cancer (PC) will affect 48,960 persons in the United States and will result in 40,560 deaths in 2015, according to the American Cancer Society. On a global basis, at least 337,000 persons will be diagnosed with PC. The incidence of PC has increased slightly in the United States, though worldwide cases are likely to increase substantially due to the influence of cigarette smoking, rising obesity and type II diabetes. The development of PC is related to a state of chronic inflammation a...
#1Alexander P. Stark (UCLA: University of California, Los Angeles)H-Index: 8
#2O. Joe Hines (UCLA: University of California, Los Angeles)H-Index: 32
Malignant biliary obstruction, duodenal, and gastric outlet obstruction, and tumor-related pain are the complications of unresectable pancreatic adenocarcinoma that most frequently require palliative intervention. Surgery involving biliary bypass with or without gastrojejunostomy was once the mainstay of treatment in these patients. However, advances in non-operative techniques鈥攎ost notably the widespread availability of endoscopic biliary and duodenal stents鈥攈ave shifted the paradigm of treatme...
#1Patrick Maisonneuve (NYMC: New York Medical College)H-Index: 136
#2Albert B. Lowenfels (NYMC: New York Medical College)H-Index: 67
Background: The aetiology of pancreatic cancer (PC) has been extensively studied and is the subject of numerous meta-analyses and pooled analyses. We have summarized results from these pooled and meta-analytical studies to estimate the fraction of PCs attributable to each of the identified risk factors. Methods: Using a comprehensive strategy, we retrieved 117 meta-analytical or pooled reports dealing with the association between specific risk factors and PC risk. We combined estimates of relati...
#1Claudio Ricci (UNIBO: University of Bologna)H-Index: 30
#2Riccardo Casadei (UNIBO: University of Bologna)H-Index: 33
Last. Francesco Minni (UNIBO: University of Bologna)H-Index: 27
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Background Laparoscopic distal pancreatectomy was proposed as an oncologically safe approach for pancreatic ductal adenocarcinoma.
#1Saowanee Ngamruengphong (Mayo Clinic)H-Index: 33
#2Kristi M. Swanson (Mayo Clinic)H-Index: 7
Last. Michael B. Wallace (Mayo Clinic)H-Index: 88
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Objective Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) allows preoperative tissue confirmation of malignancy, but fear of tumour cell dissemination along the needle track has limited its use. We hypothesised that if tumour cell dissemination occurs with EUS-FNA, survival after complete resection would be impaired. We aimed to evaluate the association of preoperative EUS-FNA with long-term outcomes of patients with resected pancreatic cancer. Design Using the linked Surveillance,...
#1Irene Esposito (TUM: Technische Universit盲t M眉nchen)H-Index: 71
#2Bj枚rn Konukiewitz (TUM: Technische Universit盲t M眉nchen)H-Index: 22
Last. G眉nter Kl枚ppel (TUM: Technische Universit盲t M眉nchen)H-Index: 54
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Despite major improvements concerning its diagnosis and treatment, pancreatic ductal adenocarcinoma (PDAC) remains an aggressive disease with an extremely poor prognosis. Pathology, as interface discipline between basic and clinical medicine, has substantially contributed to the recent developments and has laid the basis for further progress. The definition and classification of precursor lesions of PDAC and their molecular characterization is a fundamental step for the potential identification ...
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Objective: This large international cohort study aimed to investigate the associations of examined lymph node (ELN) number with accurate staging and long-term survival in pancreatic adenocarcinoma (PaC) and to robustly determine the minimal and optimal ELN thresholds. Summary Background Data: ELN number is an important quality metric in cancer care. The recommended minimal ELN number in PaC to accurately stage cancer varies greatly across guidelines, and the optimal number especially to adequate...
Abstract null null Introduction null The main objective of this study is to determine whether our unit meets the quality standards required by the scientific community from the reference centers for pancreatic surgery in terms of peri-operative results. The secondary objectives are to compare the different pancreatic surgery techniques performed in terms of early post-operative morbidity and mortality and to analyze the impact of the resections added in these terms. null null null Method null De...
#1Shaoshan Mai (Gda艅sk Medical University)
#2Iwona Inkielewicz-Stepniak (Gda艅sk Medical University)H-Index: 20
Platelets have been recognized as key players in hemostasis, thrombosis and cancer. Preclinical and clinical researches evidenced that tumorigenesis and metastasis can be promoted by platelets through a wide variety of crosstalk between cancer cells and platelets. Pancreatic cancer is a devastating disease with high morbidity and mortality worldwide. Although the relationship between pancreatic cancer and platelets in clinical diagnosis is described, the interplay between pancreatic cancer and p...
#1Giamaica ContiH-Index: 17
#2Martina PiteaH-Index: 3
Last. Pierpaolo CeciH-Index: 27
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Pancreatic cancer (PC) represents an intriguing topic for researchers. To date, the prognosis of metastasized PC is poor with just 7% of patients exceeding a five-year survival period. Thus, molecular modifications of existing drugs should be developed to change the course of the disease. Our previously generated nanocages of Mitoxantrone (MIT) encapsulated in human H-chain Ferritin (HFt), designated as HFt-MP-PASE-MIT, has shown excellent tumor distribution and extended serum half-life meriting...
#1Hokun Kim (Catholic University of Korea)
#2Dong Hwan Kim (Catholic University of Korea)H-Index: 5
Last. Sung Eun Rha (Catholic University of Korea)H-Index: 26
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To compare the prognosis of pancreatic ductal adenocarcinoma (PDAC) after curative resection according to the type of intratumoral fluid鈥揷ontaining area identified on MRI. This retrospective study included 112 consecutive patients who underwent upfront surgery with margin-negative resection between 2012 and 2019. All patients underwent MRI within 1聽month before surgery. Three radiologists independently assessed the MRI findings, determined whether intratumoral fluid鈥揷ontaining areas were present...
#1Hyun yeb Jung (Kosin University Gospel Hospital)
#2Eun Mi Lee (Kosin University Gospel Hospital)H-Index: 3
Background null Despite recent advances in first-line chemotherapy for advanced pancreatic cancer, standard treatment after the failure of initial chemotherapy has not been established. Hence, we aimed to retrospectively analyze the clinical characteristics and outcomes of second-line chemotherapy in patients with advanced pancreatic cancer. null Methods null We reviewed the clinical data of patients with advanced pancreatic cancer who underwent palliative chemotherapy at Kosin University Gospel...
#1Michael K. C. Lee (Peter MacCallum Cancer Centre)
#2Sean M. Grimmond (University of Melbourne)H-Index: 87
Last. Karen E. Sheppard (Peter MacCallum Cancer Centre)H-Index: 29
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The overall survival of pancreatic ductal adenocarcinoma (PDAC) remains poor and its incidence is rising. Targetable mutations in PDAC are rare, thus novel therapeutic approaches are needed. Protein arginine methyltransferase 5 (PRMT5) overexpression is associated with worse survival and inhibition of PRMT5 results in decreased cancer growth across multiple cancers, including PDAC. Emerging evidence also suggests that altered RNA processing is a driver in PDAC tumorigenesis and creates a partial...
#1Clara Boces-Pascual (University of Barcelona)H-Index: 1
#2Aida Mata-Ventosa (University of Barcelona)H-Index: 2
Last. Sandra P茅rez-Torras (University of Barcelona)H-Index: 13
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High-affinity uptake of natural nucleosides as well as nucleoside derivatives used in anticancer therapies is mediated by human concentrative nucleoside transporters (hCNTs). hCNT1, the hCNT family member that specifically transports pyrimidines, is also a transceptor involved in tumor progression. In particular, oncogenesis appears to be associated with hCNT1 downregulation in some cancers, although the underlying mechanisms are largely unknown. Here, we sought to address changes in colorectal ...
#3Jae Hyeong Kim (Seoul National University Bundang Hospital)H-Index: 8
Treatment outcomes between FOLFIRINOX (5-fluorouracil, leucovorin, irinotecan, and oxaliplatin) and GNP (gemcitabine with albumin-bound paclitaxel) as first-line chemotherapy regimens for metastatic pancreatic cancer (PC) were assessed according to ethnic groups categorized as Western or Asian subgroups. PubMed, EMBASE, and Cochrane library were searched. Thirteen studies were eligible in this meta-analysis. Overall survival was not significantly different between FOLFIRINOX and GNP (HR 1.00, 95...
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