Staphylococcus aureus IsdB Is a Hemoglobin Receptor Required for Heme Iron Utilization
Abstract
The pathogenesis of human infections caused by the gram-positive microbe Staphylococcus aureus has been previously shown to be reliant on the acquisition of iron from host hemoproteins. The iron-regulated surface determinant system (Isd) encodes a heme transport apparatus containing three cell wall-anchored proteins (IsdA, IsdB, and IsdH) that are exposed on the staphylococcal surface and hence have the potential to interact with human...
Paper Details
Title
Staphylococcus aureus IsdB Is a Hemoglobin Receptor Required for Heme Iron Utilization
Published Date
Dec 15, 2006
Journal
Volume
188
Issue
24
Pages
8421 - 8429
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