A Review of the ADAMTS Family, Pharmaceutical Targets of the Future

Volume: 15, Issue: 20, Pages: 2359 - 2374
Published: Jul 1, 2009
Abstract
The disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family of metalloproteases consists of 19 members. These enzymes play an important role in the turnover of extracellular matrix proteins in various tissues and their altered regulation has been implicated in diseases such as cancer, arthritis and atherosclerosis. Unlike other metalloproteinases, ADAMTS members demonstrate a narrow substrate specificity due to the various...
Paper Details
Title
A Review of the ADAMTS Family, Pharmaceutical Targets of the Future
Published Date
Jul 1, 2009
Volume
15
Issue
20
Pages
2359 - 2374
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