Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity.
Abstract
The fibroblast growth factors (FGFs), and the corresponding receptors, are implicated in more than just the regulation of epithelial cell proliferation and differentiation. Specifically, FGF23 is a regulator of serum inorganic phosphate levels, and mice deficient in FGF receptor-4 have altered cholesterol metabolism. The recently described FGF19 is unusual in that it is nonmitogenic and appears to interact only with FGF receptor-4. Here, we...
Paper Details
Title
Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity.
Published Date
May 1, 2002
Journal
Volume
143
Issue
5
Pages
1741 - 1747
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Notes
History