RORγt+hematopoietic cells are necessary for tumor cell proliferation during colitis-associated tumorigenesis in mice
Abstract
Colorectal cancer (CRC) is one of the most common tumor entities. In patients with inflammatory bowel diseases, the development of colitis-associated colon cancer is considered a dangerous long-term complication. IL-17A and the transcription factor retinoic acid receptor-related orphan receptor γt (RORγt) play fundamental roles in the pathogenesis of inflammatory bowel diseases; in human studies, we detected a dense infiltration of...
Paper Details
Title
RORγt+hematopoietic cells are necessary for tumor cell proliferation during colitis-associated tumorigenesis in mice
Published Date
May 15, 2015
Volume
45
Issue
6
Pages
1667 - 1679
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