Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs
Abstract
We report that breast cancer cells that infiltrate the lungs support their own metastasis-initiating ability by expressing tenascin C (TNC). We find that the expression of TNC, an extracellular matrix protein of stem cell niches, is associated with the aggressiveness of pulmonary metastasis. Cancer cell-derived TNC promotes the survival and outgrowth of pulmonary micrometastases. TNC enhances the expression of stem cell signaling components,...
Paper Details
Title
Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs
Published Date
Jun 26, 2011
Journal
Volume
17
Issue
7
Pages
867 - 874
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Notes
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