A Transforming Growth Factor β-Induced Smad3/Smad4 Complex Directly Activates Protein Kinase A
Abstract
Transforming growth factor β (TGFβ) interacts with cell surface receptors to initiate a signaling cascade critical in regulating growth, differentiation, and development of many cell types. TGFβ signaling involves activation of Smad proteins which directly regulate target gene expression. Here we show that Smad proteins also regulate gene expression by using a previously unrecognized pathway involving direct interaction with protein kinase A...
Paper Details
Title
A Transforming Growth Factor β-Induced Smad3/Smad4 Complex Directly Activates Protein Kinase A
Published Date
Mar 1, 2004
Volume
24
Issue
5
Pages
2169 - 2180
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