Power failure: why small sample size undermines the reliability of neuroscience

Low-powered studies lead to overestimates of effect size and low reproducibility of results. In this Analysis article, Munafò and colleagues show that the average statistical power of studies in the neurosciences is very low, discuss ethical implications of low-powered studies and provide recommendations to improve research practices. A study with low statistical power has a reduced chance of detecting a true effect, but it is less well...