Loss of MMP-2 in osteoblasts upregulates osteopontin and bone sialoprotein expression in a circuit regulating bone homeostasis

Summary Multicentric osteolysis with arthropathy (MOA; MIM 605156) is an inherited osteolyses/arthritis syndrome resulting from loss of MMP-2. We recently demonstrated that Mmp2-/- mice represent a unique model for the study of the human disease, sharing many features of the human syndrome including skeletal dysplasia and defects in osteoblast behavior. We therefore sought to explore, secondary molecular effects of MMP-2 loss which coexist with...