Ketosis may promote brain macroautophagy by activating Sirt1 and hypoxia-inducible factor-1

Volume: 85, Issue: 5, Pages: 631 - 639
Published: Nov 1, 2015
Abstract
Ketogenic diets are markedly neuroprotective, but the basis of this effect is still poorly understood. Recent studies demonstrate that ketone bodies increase neuronal levels of hypoxia-inducible factor-1α (HIF-1α), possibly owing to succinate-mediated inhibition of prolyl hydroxylase activity. Moreover, there is reason to suspect that ketones can activate Sirt1 in neurons, in part by increasing cytoplasmic and nuclear levels of Sirt1's obligate...
Paper Details
Title
Ketosis may promote brain macroautophagy by activating Sirt1 and hypoxia-inducible factor-1
Published Date
Nov 1, 2015
Volume
85
Issue
5
Pages
631 - 639
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