NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B(4) in a murine model of gout.
Abstract
Objective
Deposition of monosodium urate monohydrate (MSU) crystals in the joints promotes an intense inflammatory response and joint dysfunction. This study evaluated the role of the NLRP3 inflammasome and 5-lipoxygenase (5-LOX)–derived leukotriene B4 (LTB4) in driving tissue inflammation and hypernociception in a murine model of gout.
Methods
Gout was induced by injecting MSU crystals into the joints of mice. Wild-type mice and mice...
Paper Details
Title
NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B(4) in a murine model of gout.
Published Date
Feb 1, 2012
Journal
Volume
64
Issue
2
Pages
474 - 484
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Notes
History