Splice Variant Specific Modulation of Ca V 1.2 Calcium Channel by Galectin-1 Regulates Arterial Constriction
Abstract
Ca(V)1.2 channels are essential for excitation-contraction coupling in the cardiovascular system, and alternative splicing optimizes its role. Galectin-1 (Gal-1) has been reported to regulate vascular smooth muscle cell (VSMC) function and play a role in pulmonary hypertension. We have identified Gal-1 multiple times in yeast 2-hybrid assays using the Ca(V)1.2 I-II loop as bait.Our hypothesis is that Gal-1 interacts directly with Ca(V)1.2...
Paper Details
Title
Splice Variant Specific Modulation of Ca V 1.2 Calcium Channel by Galectin-1 Regulates Arterial Constriction
Published Date
Nov 11, 2011
Journal
Volume
109
Issue
11
Pages
1250 - 1258
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