Inflammatory and Angiogenic Abnormalities in Diabetic Wound Healing: Role of Neuropeptides and Therapeutic Perspectives

Published on Mar 15, 2012in The Open Circulation & Vascular Journal
· DOI :10.2174/1874382601003010043
Ana Tellechea14
Estimated H-index: 14
,
Ermelindo C. Leal22
Estimated H-index: 22
+ 1 AuthorsEugenia Carvalho33
Estimated H-index: 33
(UC: University of Coimbra)
Sources
Abstract
Diabetic foot ulceration (DFU) is one of the most costly and debilitating complications of diabetes and is the leading cause of non-traumatic amputations, affecting 15% of the diabetic population. Impaired wound healing in diabetic patients without large-vessel disease has been attributed to microvascular dysfunction, neuropathy, and abnormal cellular and inflammatory responses. These abnormalities have been examined mainly in animal models although a few studies have been undertaken in diabetic patients. This review provides an overview of the inflammatory and vascular abnormali- ties in DFU and emphasises the role of angiogenic growth factors, endothelial progenitor cells (EPCs), and neuropeptides as mediators of wound healing and potential therapeutic agents for these chronic, non-healing ulcers.
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This research was supported by Research Grants from the Ministry of Research, Technology and Higher Education for funding period of 2017.
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