Pralidoxime in Acute Organophosphorus Insecticide Poisoning—A Randomised Controlled Trial

Background Poisoning with organophosphorus (OP) insecticides is a major global public health problem, causing an estimated 200,000 deaths each year. Although the World Health Organization recommends use of pralidoxime, this antidote's effectiveness remains unclear. We aimed to determine whether the addition of pralidoxime chloride to atropine and supportive care offers benefit. Methods and Findings We performed a double-blind randomised...