An interleukin-17–mediated paracrine network promotes tumor resistance to anti-angiogenic therapy
Abstract
Although angiogenesis inhibitors have provided substantial clinical benefit as cancer therapeutics, their use is limited by resistance to their therapeutic effects. While ample evidence indicates that such resistance can be influenced by the tumor microenvironment, the underlying mechanisms remain incompletely understood. Here, we have uncovered a paracrine signaling network between the adaptive and innate immune systems that is associated with...
Paper Details
Title
An interleukin-17–mediated paracrine network promotes tumor resistance to anti-angiogenic therapy
Published Date
Aug 4, 2013
Journal
Volume
19
Issue
9
Pages
1114 - 1123
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Notes
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