Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb

Δ9-tetrahydrocannabinol binds cannabinoid (CB1 and CB2) receptors, which are activated by endogenous compounds (endocannabinoids) and are involved in a wide range of physiopathological processes (e.g. modulation of neurotransmitter release, regulation of pain perception, and of cardiovascular, gastrointestinal and liver functions). The well-known psychotropic effects of Δ9-tetrahydrocannabinol, which are mediated by activation of brain CB1...