Dietary Fish Oil Aggravates Paracetamol‐Induced Liver Injury in Mice

Paracetamol (APAP) hepatotoxicity remains the leading cause of drug-induced liver failure. Fish oil, which contains ω-3 fatty acids, has demonstrated therapeutic efficacy in several models of liver disease. Evidence for its use in APAP intoxication, however, is conflicting. The effects of fish oil supplementation on APAP-induced liver failure were investigated.Ten C57BL6/J mice were fed a diet based on menhaden fish oil (MEN) or soybean oil...