Proteinase activated receptor (PAR) involvement in mediating arthritis pain and inflammation
Abstract
Proteinase activated receptors (PARs) are a newly identified family of G-protein-coupled receptors that are activated by proteinases released into tissues during inflammation. Evidence has accumulated which shows that PARs can exhibit both anti- and pro-inflammatory properties in different organ systems. During arthritis, proteinases are known to be released into the joint where they orchestrate tissue remodelling and degeneration. By activating...
Paper Details
Title
Proteinase activated receptor (PAR) involvement in mediating arthritis pain and inflammation
Published Date
Jan 30, 2009
Journal
Volume
58
Issue
3
Pages
119 - 126
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Notes
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