Nicotine Promotes Initiation and Progression of KRAS-Induced Pancreatic Cancer via Gata6-Dependent Dedifferentiation of Acinar Cells in Mice
Abstract
Background & AimsAlthough smoking is a leading risk factor for pancreatic ductal adenocarcinoma (PDAC), little is known about the mechanisms by which smoking promotes initiation or progression of PDAC.MethodsWe studied the effects of nicotine administration on pancreatic cancer development in Kras+/LSLG12Vgeo;Elas-tTA/tetO-Cre (Ela-KRAS) mice, Kras+/LSLG12D;Trp53+/LSLR172H;Pdx-1-Cre (KPC) mice (which express constitutively active forms of KRAS),...
Paper Details
Title
Nicotine Promotes Initiation and Progression of KRAS-Induced Pancreatic Cancer via Gata6-Dependent Dedifferentiation of Acinar Cells in Mice
Published Date
Nov 1, 2014
Journal
Volume
147
Issue
5
Pages
1119 - 1133.e4
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