PD-L1 Expression in Triple-Negative Breast Cancer
Abstract
Early-phase trials targeting the T-cell inhibitory molecule programmed cell death ligand 1 (PD-L1) have shown clinical efficacy in cancer. This study was undertaken to determine whether PD-L1 is overexpressed in triple-negative breast cancer (TNBC) and to investigate the loss of PTEN as a mechanism of PD-L1 regulation. The Cancer Genome Atlas (TCGA) RNA sequencing data showed significantly greater expression of the PD-L1 gene in TNBC (n = 120)...
Paper Details
Title
PD-L1 Expression in Triple-Negative Breast Cancer
Published Date
Apr 1, 2014
Journal
Volume
2
Issue
4
Pages
361 - 370
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