GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression
Abstract
Despite advances in our understanding of breast cancer, patients with metastatic disease have poor prognoses. GATA3 is a transcription factor that specifies and maintains mammary luminal epithelial cell fate, and its expression is lost in breast cancer, correlating with a worse prognosis in human patients. Here, we show that GATA3 promotes differentiation, suppresses metastasis and alters the tumour microenvironment in breast cancer by inducing...
Paper Details
Title
GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression
Published Date
Feb 1, 2013
Journal
Volume
15
Issue
2
Pages
201 - 213
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Notes
History