Molecular Architecture of the Goodpasture Autoantigen in Anti-GBM Nephritis
Abstract
In Goodpasture's disease, circulating autoantibodies bind to the noncollagenous-1 (NC1) domain of type IV collagen in the glomerular basement membrane (GBM). The specificity and molecular architecture of epitopes of tissue-bound autoantibodies are unknown. Alport's post-transplantation nephritis, which is mediated by alloantibodies against the GBM, occurs after kidney transplantation in some patients with Alport's syndrome. We compared the...
Paper Details
Title
Molecular Architecture of the Goodpasture Autoantigen in Anti-GBM Nephritis
Published Date
Jul 22, 2010
Volume
363
Issue
4
Pages
343 - 354
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