METABOLISM OF MELATONIN BY HUMAN CYTOCHROMES P450
Abstract
In humans, the pineal hormone melatonin (MEL) is principally metabolized to 6-hydroxymelatonin (6-HMEL), which is further conjugated with sulfate and excreted in urine. MEL O-demethylation represents a minor reaction. The exact role of individual human cytochromes P450 (P450s) in these pathways has not been established. We used a panel of 11 recombinant human P450 isozymes to investigate for the first time the 6-hydroxylation and...
Paper Details
Title
METABOLISM OF MELATONIN BY HUMAN CYTOCHROMES P450
Published Date
Dec 22, 2004
Volume
33
Issue
4
Pages
489 - 494
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