Tensional homeostasis and the malignant phenotype
Abstract
Tumors are stiffer than normal tissue, and tumors have altered integrins. Because integrins are mechanotransducers that regulate cell fate, we asked whether tissue stiffness could promote malignant behavior by modulating integrins. We found that tumors are rigid because they have a stiff stroma and elevated Rho-dependent cytoskeletal tension that drives focal adhesions, disrupts adherens junctions, perturbs tissue polarity, enhances growth, and...
Paper Details
Title
Tensional homeostasis and the malignant phenotype
Published Date
Sep 1, 2005
Journal
Volume
8
Issue
3
Pages
241 - 254
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History