Defining the COX inhibitor selectivity of NSAIDs: implications for understanding toxicity.

Volume: 3, Issue: 6, Pages: 769 - 776
Published: Nov 1, 2010
Abstract
The hypothesis that the anti-inflammatory activity of NSAIDs derives from COX inhibition is well established. It also underpins the accepted mechanism of the gastrointestinal and renal toxicity of NSAIDs. However, in terms of NSAID-induced cardiovascular toxicity, is COX inhibition then guilty by association? Multiple experimental models of COX-1/COX-2 inhibition have enabled ranking of the relative inhibitory activity of NSAIDs. Inhibition is...
Paper Details
Title
Defining the COX inhibitor selectivity of NSAIDs: implications for understanding toxicity.
Published Date
Nov 1, 2010
Volume
3
Issue
6
Pages
769 - 776
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