ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis

The transmembrane metalloprotease‐disintegrin ADAM 8 mediates cell adhesion and shedding of ligands, receptors and extracellular matrix components. Here, we report that ADAM 8 is abundantly expressed in breast tumors and derived metastases compared to normal tissue, especially in triple‐negative breast cancers ( TNBC s). Furthermore, high ADAM 8 levels predicted poor patient outcome. Consistently, ADAM 8 promoted an aggressive phenotype of TNBC...