Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation

Cyclin A is shown to maintain unstable kinetochore–microtubule (k–MT) attachments in prometaphase in order to allow for error correction; at the prometaphase–metaphase switch, k-MT attachments are stabilized when cyclin A drops below threshold levels. During metaphase, chromosomes become aligned at the mitotic spindle through the formation of bi-oriented attachments of kinetochores to spindle microtubules. However, kinetochore–microtubule...