Epigallocatechin gallate-loaded polysaccharide nanoparticles for prostate cancer chemoprevention

Polysaccharide nanoparticles were studied as drug delivery vehicles for chemopreventive agents.Green tea polyphenol epigallocatechin-3-gallate (EGCG) was incorporated into a carbohydrate matrix of gum arabic and maltodextrin with an encapsulation efficiency of approximately 85%.Encapsulated EGCG retained its biological activity, reducing the cell viability and inducing apoptosis of Du145 prostate cancer cells. Clonogenic assay demonstrated that...