Determinants of laminin polymerization revealed by the structure of the α5 chain amino‐terminal region
Abstract
The polymerization of laminin into a cell-associated network--a key step in basement membrane assembly--is mediated by the laminin amino-terminal (LN) domains at the tips of the three short arms of the laminin αβγ-heterotrimer. The crystal structure of a laminin α5LN-LE1-2 fragment shows that the LN domain is a β-jelly roll with several elaborate insertions that is attached like a flower head to the stalk-like laminin-type epidermal growth...
Paper Details
Title
Determinants of laminin polymerization revealed by the structure of the α5 chain amino‐terminal region
Published Date
Feb 11, 2011
Journal
Volume
12
Issue
3
Pages
276 - 282
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Notes
History