Antipermeability and antiproliferative effects of standard and frozen bevacizumab on choroidal endothelial cells

Bevacizumab is an antiangiogenic compound developed to target tumour vessels. Its off-label use in ophthalmology requires in vitro testing on ocular cells.To quantify the antipermeability and antiproliferative effects of bevacizumab on cultured choroidal endothelial cells (CECs). It was examined whether deep-freezing of bevacizumab attenuates its antiangiogenic activity.Porcine CECs were cultured in permeable insert systems. Permeability of the...