Design of fully active FGF-1 variants with increased stability

Volume: 17, Issue: 8, Pages: 603 - 611
Published: Sep 23, 2004
Abstract
Fibroblast growth factor 1 is a powerful mitogen playing an important role in morphogenesis, angiogenesis and wound healing and is therefore of potential medical interest. Using homologous sequence and structure comparisons, we designed and constructed 16 mutants of FGF-1 with increased thermodynamic stability, as determined by chemical and heat denaturation. For multiple mutants, additive effects on stability were observed, providing mutants up...
Paper Details
Title
Design of fully active FGF-1 variants with increased stability
Published Date
Sep 23, 2004
Volume
17
Issue
8
Pages
603 - 611
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