Metformin Prevents the Development of Chronic Heart Failure in the SHHF Rat Model
Abstract
Insulin resistance is a recently identified mechanism involved in the pathophysiology of chronic heart failure (CHF). We investigated the effects of two insulin-sensitizing drugs (metformin and rosiglitazone) in a genetic model of spontaneously hypertensive, insulin-resistant rats (SHHF). Thirty SHHF rats were randomized into three treatment groups as follows: 1) metformin (100 mg/kg per day), 2) rosiglitazone (2 mg/kg per day), and 3) no drug....
Paper Details
Title
Metformin Prevents the Development of Chronic Heart Failure in the SHHF Rat Model
Published Date
Mar 14, 2012
Journal
Volume
61
Issue
4
Pages
944 - 953
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