Epidermal growth factor receptor inhibitors for treatment of orbital squamous cell carcinoma.

Published on Dec 1, 2012in Archives of Ophthalmology
· DOI :10.1001/ARCHOPHTHALMOL.2012.2515
Tarek El-Sawy13
Estimated H-index: 13
(University of Texas MD Anderson Cancer Center),
Anita L. Sabichi37
Estimated H-index: 37
(University of Texas MD Anderson Cancer Center)
+ 5 AuthorsBita Esmaeli57
Estimated H-index: 57
Sources
Abstract
📖 Papers frequently viewed together
57 Citations
17 Citations
References6
Newest
#1Carol M. LewisH-Index: 16
#2Bonnie S. GlissonH-Index: 73
Last. Randal S. WeberH-Index: 96
view all 11 authors...
Purpose: To determine the disease control rate and toxicity of treating patients with aggressive cutaneous squamous cell carcinoma (CSCC) with neoadjuvant gefitinib. Experimental Design: A prospective phase II clinical trial evaluating neoadjuvant gefitinib given prior to standard treatment with surgery and/or radiotherapy. Patients with stable disease after one cycle received escalated doses. Patients who responded were given gefitinib during radiation therapy, as well as maintenance therapy af...
120 CitationsSource
#1Eve MaubecH-Index: 29
#2Peter PetrowH-Index: 12
Last. Marie-Françoise AvrilH-Index: 70
view all 19 authors...
Purpose To evaluate the efficacy and safety of cetuximab, a monoclonal antibody that inhibits the epidermal growth factor receptor (EGFR), as a first-line monotherapy in patients with unresectable squamous cell carcinoma of the skin (SCCS). Patients and Methods Thirty-six patients received cetuximab (initial dose of 400 mg/m 2 followed by subsequent weekly doses of 250 mg/m 2 ) for at least 6 weeks with a 48-week follow-up. The primary end point was the disease control rate (DCR) at 6 weeks (acc...
265 CitationsSource
#1J. Simon W. Stewart (Charing Cross Hospital)H-Index: 4
#2Ezra E.W. CohenH-Index: 78
Last. Everett E. VokesH-Index: 119
view all 17 authors...
Purpose To compare survival in patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN) treated with gefitinib 250 or 500 mg/day or standard methotrexate. Patients and Methods Four hundred eighty-six patients with recurrent SCCHN were randomly assigned to oral gefitinib 250 mg/day, gefitinib 500 mg/day, or methotrexate 40 mg/m 2 intravenously weekly. Primary end point was overall survival, secondary end points were objective response rate (ORR), safety, symptom ...
288 CitationsSource
#1Jan B. Vermorken (University of Antwerp)H-Index: 87
#2Ricard MesiaH-Index: 29
Last. Ricardo Hitt (Complutense University of Madrid)H-Index: 31
view all 18 authors...
Background Cetuximab is effective in platinum-resistant recurrent or metastatic squamous-cell carcinoma of the head and neck. We investigated the efficacy of cetuximab plus platinum-based chemotherapy as first-line treatment in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck. Methods We randomly assigned 220 of 442 eligible patients with untreated recurrent or metastatic squamous-cell carcinoma of the head and neck to receive cisplatin (at a dose of 100 mg per ...
2,288 CitationsSource
#1Julie E. Bauman (UW: University of Washington)H-Index: 33
#2Keith D. Eaton (UW: University of Washington)H-Index: 22
Last. Renato G. Martins (UW: University of Washington)H-Index: 48
view all 3 authors...
Background Squamous cell carcinoma of the skin (SCCS) is rarely encountered by medical oncologists owing to success of local therapies. When advanced SCCS requires systemic palliation, treatment with conventional chemotherapy, such as cisplatin, is often precluded by a patient's age or medical comorbidities. Cetuximab is a human and mouse chimeric antibody against epidermal growth factor receptor, a tyrosine kinase receptor richly expressed by SCCS cells, including lymph node metastases. This dr...
90 CitationsSource
#1Todd R. Shepler (University of Texas MD Anderson Cancer Center)H-Index: 6
#2Victor G. PrietoH-Index: 82
Last. Bita EsmaeliH-Index: 57
view all 6 authors...
Purpose: To determine whether the tyrosine kinase epidermal growth factor receptor (EGFR) is expressed in squamous cell carcinoma of the conjunctiva. Methods: A retrospective, observational case series of 5 patients with biopsy-proven conjunctival squamous cell carcinoma treated at one institution between January 1996 and April 2004. Medical records and tissue specimens from the 5 patients were reviewed. A control specimen of normal conjunctiva was also obtained from one of the 5 patients. Immun...
20 CitationsSource
Cited By21
Newest
The management of periocular skin malignant tumours is challenging. Surgery remains the mainstay of treatment for localised eyelid cancers. For more locally advanced cancers, especially those invading the orbit, orbital exenteration has long been considered the gold standard; however, it is a highly disfiguring and traumatic surgery. The last two decades have been marked by the emergence of a new paradigm shift towards the use of ‘eye-sparing’ strategies. In the early 2000s, the first step consi...
Source
#1Rachna Meel (AIIMS: All India Institute of Medical Sciences)H-Index: 10
#2Rebika Dhiman (AIIMS: All India Institute of Medical Sciences)H-Index: 7
Last. Sameer Bakhshi (AIIMS: All India Institute of Medical Sciences)H-Index: 28
view all 6 authors...
Background/objectives:The conventional modality for management of advanced invasive ocular surface squamous neoplasia (OSSN) (AJCC grade T4 and T3 with fornicial involvement) is surgical excision w...
Source
#1Roland Hӧllhumer (University of the Witwatersrand)
#2Susan Williams (University of the Witwatersrand)H-Index: 12
Last. Pamela Michelow (National Health Laboratory Service)H-Index: 11
view all 3 authors...
Ocular surface squamous neoplasia (OSSN) is the most common ocular tumour with an incidence ranging from 0.03 to 1.9 per 100,000 persons/year. The diagnosis is made on clinical suspicion and confirmed with anterior-segment optical coherence tomography (AS-OCT), cytology, or histology. The purpose of this review is to provide an overview of the management options available for OSSN and review their success and recurrence rates. Surgery is the gold standard for the management of small OSSN lesions...
Source
Orbital exenteration is a radical and disfiguring surgery mainly performed in specialized tertiary care centers. Orbital exenteration has long been considered the treatment of choice for managing periocular tumors invading the orbit or primary orbital malignancies. Over the past decades, attention has been directed towards reducing the perioperative morbidity by developing new surgical devices and new strategies and promoting cosmetic rehabilitation by providing adequate facial prostheses. Despi...
1 CitationsSource
Tumors arising from the eyelid can be benign or malignant and are classified according to the tissue of origin. Malignant eyelid tumors can potentially be life threatening. A detailed evaluation is required to differentiate benign from malignant tumors depending on the characteristic clinical features. The standard of care involves surgical excision. Malignant eyelid tumors require complete surgical clearance with histopathologically proven negative margins. This prevents recurrences and reduces...
Source
Source
#1Oded Sagiv (University of Texas MD Anderson Cancer Center)H-Index: 8
#2Bashar M.Y. Jaber (University of Texas MD Anderson Cancer Center)H-Index: 2
Last. Bita Esmaeli (University of Texas MD Anderson Cancer Center)H-Index: 57
view all 3 authors...
The use of targeted therapy and immune checkpoint inhibitors have significantly contributed to the treatment of patients with locally advanced, unresectable metastatic periocular cancers. Sonic Hedgehog inhibitors are used to treat locally advanced or metastatic periocular basal cell carcinoma and have been found to enable a less-extensive definitive surgery. Epidermal growth factor receptor antagonists have been used to treat patients with locally advanced periocular squamous cell carcinoma wit...
1 CitationsSource
#1Abolfazl Kasaee (Tehran University of Medical Sciences)H-Index: 5
#2Bahram Eshraghi (Tehran University of Medical Sciences)H-Index: 8
Last. Mansooreh Jamshidian-Tehrani (Tehran University of Medical Sciences)H-Index: 6
view all 6 authors...
PURPOSE: Orbital exenteration is a psychologically and anatomically disfiguring procedure which indicated in some patients with malignant or progressive diseases of orbital and periorbital area. In this study, we reviewed 176 patients that underwent orbital exenteration. METHODS: This was a retrospective study of medical records from all patients who underwent orbital exenteration from March 1991 to March 2014 in oculoplastic department at an eye care center. Demographic data, diagnosis, site of...
6 CitationsSource
Last. O. Sanmartín JiménezH-Index: 2
view all 3 authors...
Resumen En ocasiones el carcinoma epidermoide cutaneo se caracteriza por tener un mayor riesgo de desarrollar recurrencia locorregional y ocasionalmente metastasis a distancia. Existen diversos factores clinico-patologicos de reconocido valor pronostico, entre ellos la presencia de infiltracion perineural. Esta consiste en la diseminacion de celulas tumorales a traves de los nervios, siendo en la mayoria de los casos un hallazgo incidental. Cuando aparecen sintomas y/o evidencia radiologica de l...
4 CitationsSource
Abstract Cutaneous squamous cell carcinoma is sometimes characterized by an increased risk of locoregional recurrence and occasionally distant metastasis. Several clinical and pathological factors, including perineural invasion, have been shown to have prognostic value in this setting. Perineural invasion, that is, the spread of tumor cells into the space surrounding a nerve, is usually an incidental finding. In the presence of symptoms or radiographic evidence of perineural spread, the diagnosi...
3 CitationsSource