β2-Glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome
Abstract
The antiphospholipid syndrome is defined by the presence of antiphospholipid antibodies in blood of patients with thrombosis or fetal loss. There is ample evidence that β2-glycoprotein I (β2GPI) is the major antigen for antiphospholipid antibodies. The autoantibodies recognize β2GPI when bound to anionic surfaces and not in solution. We showed that β2GPI can exist in at least 2 different conformations: a circular plasma conformation and an...
Paper Details
Title
β2-Glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome
Published Date
Aug 26, 2010
Journal
Volume
116
Issue
8
Pages
1336 - 1343
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