Phenotyping the Function of TRPV1-Expressing Sensory Neurons by Targeted Axonal Silencing
Abstract
Specific somatosensations may be processed by different subsets of primary afferents. C-fibers expressing heat-sensitive TRPV1 channels are proposed, for example, to be heat but not mechanical pain detectors. To phenotype in rats the sensory function of TRPV1(+) afferents, we rapidly and selectively silenced only their activity, by introducing the membrane-impermeant sodium channel blocker QX-314 into these axons via the TRPV1 channel pore....
Paper Details
Title
Phenotyping the Function of TRPV1-Expressing Sensory Neurons by Targeted Axonal Silencing
Published Date
Jan 2, 2013
Journal
Volume
33
Issue
1
Pages
315 - 326
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