HCV infection selectively impairs type I but not type III IFN signaling.
Abstract
A stable and persistent Hepatitis C virus (HCV) replication cell culture model was developed to examine clearance of viral replication during long-term treatment using interferon-α (IFN-α), IFN-λ, and ribavirin (RBV). Persistently HCV-infected cell culture exhibited an impaired antiviral response to IFN-α+RBV combination treatment, whereas IFN-λ treatment produced a strong and sustained antiviral response that cleared HCV replication. HCV...
Paper Details
Title
HCV infection selectively impairs type I but not type III IFN signaling.
Published Date
Jan 1, 2014
Volume
184
Issue
1
Pages
214 - 229
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