Implantation of dendritic cells in injured adult spinal cord results in activation of endogenous neural stem/progenitor cells leading to de novo neurogenesis and functional recovery
Abstract
We report a treatment for spinal cord injury involving implantation of dendritic cells (DCs), which act as antigen‐presenting cells in the immune system. The novel mechanisms underlying this treatment produce functional recovery. Among the immune cells tested, DCs showed the strongest activity inducing proliferation and survival of neural stem/progenitor cells (NSPCs) in vitro. Furthermore, in DC‐implanted adult mice, endogenous NSPCs in the...
Paper Details
Title
Implantation of dendritic cells in injured adult spinal cord results in activation of endogenous neural stem/progenitor cells leading to de novo neurogenesis and functional recovery
Published Date
Apr 12, 2004
Volume
76
Issue
4
Pages
453 - 465
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