17β‐estradiol regulates estrogen receptor α monoubiquitination

Monoubiquitination is a nonproteolytic signal involved in a network of several different physiological processes. Recently, monoubiquitination has been discovered as a new post‐transductional modification of the estrogen receptor α (ERα). However, at present no information is available about the role of the cognate ligand 17β‐estradiol (E2) in modulating this receptor post‐transductional modification. Thus, we studied the E2‐dependent modulation...