A Novel Skeletal Drug Delivery System Using Self‐Setting Calcium Phosphate Cement. 7. Effect of Biological Factors on lndomethacin Release from the Cement Loaded on Bovine Bone

The use of self‐setting bioactive calcium phosphate cement containing indomethacin as a model drug in bovine bone was investigated by means of an in vitro drug release test, mercury porosimetry, and scanning electron microscopy (SEM). Calcium phosphate cements containing 2 and 5% indomethacin after being mixed with dilute phosphoric acid were applied to defect sites and the medullary cavity of bovine bone and transformed into hydroxyapatite. The...