Influence of Batch Cooling Crystallization on Mannitol Physical Properties and Drug Dispersion from Dry Powder Inhalers

Volume: 12, Issue: 6, Pages: 3006 - 3017
Published: May 23, 2012
Abstract
This study provides, for the first time, an evaluation of the physicochemical properties of batch cooling crystallized mannitol particles combined with how these properties correlated with the inhalation performance from a dry powder inhaler (Aerolizer). The results showed that the type of polymorph changed from β-form (commercial mannitol) to mixtures of β- + δ-mannitol (cooling crystallized mannitol crystals). In comparison to mannitol...
Paper Details
Title
Influence of Batch Cooling Crystallization on Mannitol Physical Properties and Drug Dispersion from Dry Powder Inhalers
Published Date
May 23, 2012
Volume
12
Issue
6
Pages
3006 - 3017
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