Expression of Dickkopf genes is strongly reduced in malignant melanoma.

Volume: 25, Issue: 36, Pages: 5027 - 5036
Published: Aug 17, 2006
Abstract
The Dickkopf (DKK) genes were originally identified as factors inducing head formation in Xenopus. The genes code for inhibitors that are involved in Wnt signaling. We speculate that loss of DKK expression plays a role in development or progression of malignant melanoma. Thus, we evaluated melanoma cell lines and tissue samples of malignant melanoma for loss of DKK, especially DKK-3 transcription. We found that DKK-1, -2 and -3 were...
Paper Details
Title
Expression of Dickkopf genes is strongly reduced in malignant melanoma.
Published Date
Aug 17, 2006
Journal
Volume
25
Issue
36
Pages
5027 - 5036
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