Safety, tolerability, and pharmacokinetics of single ascending doses of synthetic genistein (Bonistein) in healthy volunteers.
Abstract
Genistein, an isoflavone and phytoestrogen predominantly found in soy, is considered a potentially safe therapeutic option to prevent postmenopausal bone loss. A novel purified product consisting of 99.4% synthetic genistein aglycone was investigated in a phase 1 clinical study to assess safety and tolerability in healthy volunteers as well as to obtain pharmacokinetic data. Single oral doses of 30, 60, 150, or 300 mg were administered to 40...
Paper Details
Title
Safety, tolerability, and pharmacokinetics of single ascending doses of synthetic genistein (Bonistein) in healthy volunteers.
Published Date
Jan 1, 2005
Journal
Volume
22
Issue
1
Pages
65 - 78
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Notes
History