TSC2/mTORC1 signaling controls Paneth and goblet cell differentiation in the intestinal epithelium
Abstract
The intestinal mucosa undergoes a continual process of proliferation, differentiation and apoptosis, which is regulated by multiple signaling pathways. Notch signaling is critical for the control of intestinal stem cell maintenance and differentiation. However, the precise mechanisms involved in the regulation of differentiation are not fully understood. Previously, we have shown that tuberous sclerosis 2 (TSC2) positively regulates the...
Paper Details
Title
TSC2/mTORC1 signaling controls Paneth and goblet cell differentiation in the intestinal epithelium
Published Date
Feb 5, 2015
Journal
Volume
6
Issue
2
Pages
e1631 - e1631
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Notes
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