Multifunctioning pH‐responsive nanoparticles from hierarchical self‐assembly of polymer brush for cancer drug delivery

Polymer nanoparticles are extensively explored as drug carriers but they generally have issues of premature burst drug release, slow cellular uptake, and retention in acidic intracellular compartments. Herein, we report multifunctioning three‐layered nanoparticles (3LNPs) that can overcome these problems. The 3LNPs have a poly(ε‐caprolactone) (PCL) core, a pH‐responsive poly[2‐(N,N‐diethylamino)ethyl methacrylate](PDEA) middle layer and a...