A universal strategy for stable intracellular antibodies

Volume: 303, Issue: 1, Pages: 19 - 39
Published: Aug 1, 2005
Abstract
null null The expression of intracellular antibodies (intrabodies) in mammalian cells has provided a powerful tool to manipulate microbial and cellular signalling pathways in a highly precise manner. However, several technical hurdles have thus far restricted their more widespread use. In particular, single-chain antibodies (scFvs) have been reported to fold poorly in the reducing environment of the cytoplasm and as such there has been a...
Paper Details
Title
A universal strategy for stable intracellular antibodies
Published Date
Aug 1, 2005
Volume
303
Issue
1
Pages
19 - 39
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