Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity
Abstract
Using natural killer T (NKT) cell-deficient mice, we show here that allergen-induced airway hyperreactivity (AHR), a cardinal feature of asthma, does not develop in the absence of V(alpha)14i NKT cells. The failure of NKT cell-deficient mice to develop AHR is not due to an inability of these mice to produce type 2 T-helper (Th2) responses because NKT cell-deficient mice that are immunized subcutaneously at non-mucosal sites produce normal...
Paper Details
Title
Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity
Published Date
Mar 31, 2003
Journal
Volume
9
Issue
5
Pages
582 - 588
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Notes
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