REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons
Abstract
Expression of the type II voltage-dependent sodium channel gene is restricted to neurons by a silencer element active in nonneuronal cells. We have cloned cDNA coding for a transcription factor (REST) that binds to this silencer element. Expression of a recombinant REST protein confers the ability to silence type II reporter genes in neuronal cell types lacking the native REST protein, whereas expression of a dominant negative form of REST in...
Paper Details
Title
REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons
Published Date
Mar 1, 1995
Journal
Volume
80
Issue
6
Pages
949 - 957
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